Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord

Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord

Abstract Background Spinal cord microglia plays a crucial role in the pathogenesis of neuropathic pain. However, the mechanisms underlying spinal microglial activation during neuropathic pain remain incompletely determined. Here, we investigated the role of Pellino1 (Peli1) and its interplay with sp...

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Bibliographic Details
Main Authors: Lijuan Wang, Cui Yin, Tianya Liu, Mannan Abdul, Yan Zhou, Jun-Li Cao, Chen Lu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Neuroinflammation
Subjects:
Neuropathic pain
Pellino1
Microglial activation
MAPK signaling
NF-κB
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01754-z

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http://link.springer.com/article/10.1186/s12974-020-01754-z

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