Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth

Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth

Secretory phospholipases A2 (sPLA2) exert proinflammatory actions through lipid mediators. These enzymes have been found to be elevated in many inflammatory disorders such as rheumatoid arthritis, sepsis, and atherosclerosis. The aim of this study was to evaluate the effect of harpalycin 2 (Har2), a...

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Bibliographic Details
Main Authors: Rafael M. Ximenes, Marcelo M. Rabello, Renata M. Araújo, Edilberto R. Silveira, Fábio H. R. Fagundes, Eduardo B. S. Diz-Filho, Simone C. Buzzo, Veronica C. G. Soares, Daniela de O. Toyama, Henrique H. Gaeta, Marcelo Z. Hernandes, Helena S. A. Monteiro, Marcos H. Toyama
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2012/987517

Internet

http://dx.doi.org/10.1155/2012/987517

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