Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth
Secretory phospholipases A2 (sPLA2) exert proinflammatory actions through lipid mediators. These enzymes have been found to be elevated in many inflammatory disorders such as rheumatoid arthritis, sepsis, and atherosclerosis. The aim of this study was to evaluate the effect of harpalycin 2 (Har2), a...
Main Authors: | Rafael M. Ximenes, Marcelo M. Rabello, Renata M. Araújo, Edilberto R. Silveira, Fábio H. R. Fagundes, Eduardo B. S. Diz-Filho, Simone C. Buzzo, Veronica C. G. Soares, Daniela de O. Toyama, Henrique H. Gaeta, Marcelo Z. Hernandes, Helena S. A. Monteiro, Marcos H. Toyama |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2012-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2012/987517 |
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