Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats

Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats

α-Lipoic acid (LA) is widely used for nutritional supplements as a racemic mixture, even though the R enantiomer is biologically active. After oral administration of the racemic mixture (R-α-lipoic acid (RLA) and S-α-lipoic acid (SLA) mixed at the ratio of 50:50) to rats, RLA showed higher plasma co...

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Bibliographic Details
Main Authors: Ryota Uchida, Hinako Okamoto, Naoko Ikuta, Keiji Terao, Takashi Hirota
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
α-lipoic acid
pharmacokinetics
enantioselective
gastrointestinal availability
hepatic availability
clearance
rat
Online Access:http://www.mdpi.com/1422-0067/16/9/22781

Internet

http://www.mdpi.com/1422-0067/16/9/22781

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