Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity

Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity

The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demons...

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Bibliographic Details
Main Authors: Shaunak Deota, Tandrika Chattopadhyay, Deepti Ramachandran, Eric Armstrong, Beatriz Camacho, Babukrishna Maniyadath, Amit Fulzele, Anne Gonzalez-de-Peredo, John M. Denu, Ullas Kolthur-Seetharam
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
isoform
SIRT1
SIRT1-Δ
E2
p53
PGC1α
PPARα
AKT
insulin signaling
β-oxidation
DNA damage
specificity domain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303297

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http://www.sciencedirect.com/science/article/pii/S2211124717303297

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