Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle

Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle

Objective: Physical exercise training is associated with increased glucose uptake in skeletal muscle and improved glycemic control. HDAC5, a class IIa histone deacetylase, has been shown to regulate transcription of the insulin-responsive glucose transporter GLUT4 in cultured muscle cells. In this s...

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Bibliographic Details
Main Authors: Oleksiy Klymenko, Tim Brecklinghaus, Matthias Dille, Christian Springer, Christian de Wendt, Delsi Altenhofen, Christian Binsch, Birgit Knebel, Jürgen Scheller, Christopher Hardt, Ralf Herwig, Alexandra Chadt, Paul T. Pfluger, Hadi Al-Hasani, Dhiraj G. Kabra
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
HDAC5
Interleukin 6
Diabetes
Insulin sensitivity
Exercise
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301368

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http://www.sciencedirect.com/science/article/pii/S2212877820301368

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