MiR-146a-5p Expression in Peripheral CD14+ Monocytes from Patients with Psoriatic Arthritis Induces Osteoclast Activation, Bone Resorption, and Correlates with Clinical Response

MiR-146a-5p Expression in Peripheral CD14+ Monocytes from Patients with Psoriatic Arthritis Induces Osteoclast Activation, Bone Resorption, and Correlates with Clinical Response

In psoriatic arthritis (PsA), progressive bone destruction is mediated by monocyte-derived osteoclasts. MicroRNAs (miRNAs) regulate many pathophysiological processes; however, their function in PsA patient monocytes has not been examined. This study aims to address whether specific miRNAs in CD14+ m...

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Bibliographic Details
Main Authors: Shang-Hung Lin, Ji-Chen Ho, Sung-Chou Li, Jia-Feng Chen, Chang-Chun Hsiao, Chih-Hung Lee
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Journal of Clinical Medicine
Subjects:
miR-146a-5p
osteoclast
psoriatic arthritis
Online Access:http://www.mdpi.com/2077-0383/8/1/110

Internet

http://www.mdpi.com/2077-0383/8/1/110

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