Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration

Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration

<i>KMT2D</i> encodes a methyltransferase responsible for histone 3 lysine 4 (H3K4) mono-/di-methylation, an epigenetic mark correlated with active transcription. Here, we tested the hypothesis that <i>KMT2D</i> pathogenic loss-of-function variants, which causes the Kabuki syn...

Full description

Bibliographic Details
Main Authors: Consiglia Pacelli, Iolanda Adipietro, Natascia Malerba, Gabriella Maria Squeo, Claudia Piccoli, Angela Amoresano, Gabriella Pinto, Pietro Pucci, Ji-Eun Lee, Kai Ge, Nazzareno Capitanio, Giuseppe Merla
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
Kabuki syndrome
<i>KMT2D</i>
mitochondria
Online Access:https://www.mdpi.com/2073-4409/9/7/1685

Internet

https://www.mdpi.com/2073-4409/9/7/1685

Similar Items