EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.

EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.

The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity and synapse loss. Here, we show that amyloid-β oligomers (AβOs) activate the c-Abl kinase in dendritic spines of cultured hippocampal neurons and that c-Abl kinase activity is required for AβOs-induced syn...

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Bibliographic Details
Main Authors: Lina M Vargas, Nancy Leal, Lisbell D Estrada, Adrian González, Felipe Serrano, Katherine Araya, Katia Gysling, Nibaldo C Inestrosa, Elena B Pasquale, Alejandra R Alvarez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3962387?pdf=render

Internet

http://europepmc.org/articles/PMC3962387?pdf=render

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