Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.

Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway. Here we demonstrate t...

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Bibliographic Details
Main Authors: Min Hu, Lichuan Gu, Muyang Li, Philip D Jeffrey, Wei Gu, Yigong Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1334386?pdf=render

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http://europepmc.org/articles/PMC1334386?pdf=render

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