Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal adm...

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Bibliographic Details
Main Authors: Masahiro Ohsawa, Junpei Mutoh, Shohei Yamamoto, Hideki Ono, Hiroaki Hisa
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319305298