Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal adm...

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Main Authors: Masahiro Ohsawa, Junpei Mutoh, Shohei Yamamoto, Hideki Ono, Hiroaki Hisa
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319305298
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spelling doaj-d7167e25c6e244c4a4ae5a11c00997882020-11-24T21:49:18ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011191102106Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in MiceMasahiro Ohsawa0Junpei Mutoh1Shohei Yamamoto2Hideki Ono3Hiroaki Hisa4Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, Japan; Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Corresponding author. ohsawa@phar.nagoya-cu.ac.jp on April 18, 2012 (in advance)Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanSecond Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, JapanClinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission. Keywords:: simvastatin, spinal cord, inflammationhttp://www.sciencedirect.com/science/article/pii/S1347861319305298
collection DOAJ
language English
format Article
sources DOAJ
author Masahiro Ohsawa
Junpei Mutoh
Shohei Yamamoto
Hideki Ono
Hiroaki Hisa
spellingShingle Masahiro Ohsawa
Junpei Mutoh
Shohei Yamamoto
Hideki Ono
Hiroaki Hisa
Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
Journal of Pharmacological Sciences
author_facet Masahiro Ohsawa
Junpei Mutoh
Shohei Yamamoto
Hideki Ono
Hiroaki Hisa
author_sort Masahiro Ohsawa
title Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
title_short Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
title_full Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
title_fullStr Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
title_full_unstemmed Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
title_sort effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2012-01-01
description Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission. Keywords:: simvastatin, spinal cord, inflammation
url http://www.sciencedirect.com/science/article/pii/S1347861319305298
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