Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice
Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal adm...
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doaj-d7167e25c6e244c4a4ae5a11c00997882020-11-24T21:49:18ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011191102106Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in MiceMasahiro Ohsawa0Junpei Mutoh1Shohei Yamamoto2Hideki Ono3Hiroaki Hisa4Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, Japan; Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Corresponding author. ohsawa@phar.nagoya-cu.ac.jp on April 18, 2012 (in advance)Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanLaboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JapanSecond Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka-shi, Miyazaki 882-8508, JapanClinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission. Keywords:: simvastatin, spinal cord, inflammationhttp://www.sciencedirect.com/science/article/pii/S1347861319305298 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masahiro Ohsawa Junpei Mutoh Shohei Yamamoto Hideki Ono Hiroaki Hisa |
spellingShingle |
Masahiro Ohsawa Junpei Mutoh Shohei Yamamoto Hideki Ono Hiroaki Hisa Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice Journal of Pharmacological Sciences |
author_facet |
Masahiro Ohsawa Junpei Mutoh Shohei Yamamoto Hideki Ono Hiroaki Hisa |
author_sort |
Masahiro Ohsawa |
title |
Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
title_short |
Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
title_full |
Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
title_fullStr |
Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
title_full_unstemmed |
Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice |
title_sort |
effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice |
publisher |
Elsevier |
series |
Journal of Pharmacological Sciences |
issn |
1347-8613 |
publishDate |
2012-01-01 |
description |
Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 μmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission. Keywords:: simvastatin, spinal cord, inflammation |
url |
http://www.sciencedirect.com/science/article/pii/S1347861319305298 |
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