High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling.

High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling.

BACKGROUND: Bacterial products add to mechanical ventilation in enhancing lung injury. The role of endogenous triggers of innate immunity herein is less well understood. S100A8/A9 proteins are released by phagocytes during inflammation. The present study investigates the role of S100A8/A9 proteins i...

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Bibliographic Details
Main Authors: Maria T Kuipers, Thomas Vogl, Hamid Aslami, Geartsje Jongsma, Elske van den Berg, Alexander P J Vlaar, Joris J T H Roelofs, Nicole P Juffermans, Marcus J Schultz, Tom van der Poll, Johannes Roth, Catharina W Wieland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715539?pdf=render

Internet

http://europepmc.org/articles/PMC3715539?pdf=render

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