Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors

Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors

Transketolase (TKL) plays a key role in plant photosynthesis and has been predicted to be a potent herbicide target. Homology modeling and molecular dynamics simulation were used to construct a target protein model. A target-based virtual screening was developed to discover novel potential transketo...

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Bibliographic Details
Main Authors: Jingqian Huo, Bin Zhao, Zhe Zhang, Jihong Xing, Jinlin Zhang, Jingao Dong, Zhijin Fan
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
transketolase
virtual screening
amides derivatives
synthesis
biological activity
Online Access:http://www.mdpi.com/1420-3049/23/9/2116

Internet

http://www.mdpi.com/1420-3049/23/9/2116

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