Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway.

Microbes are subjected to selective pressures during chronic infections of host tissues. Pseudomonas aeruginosa isolates with inactivating mutations in the transcriptional regulator LasR are frequently selected within the airways of people with cystic fibrosis (CF), and infection with these isolates...

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Bibliographic Details
Main Authors: Lucas R Hoffman, Anthony R Richardson, Laura S Houston, Hemantha D Kulasekara, Willm Martens-Habbena, Mikkel Klausen, Jane L Burns, David A Stahl, Daniel J Hassett, Ferric C Fang, Samuel I Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20072604/pdf/?tool=EBI