Synthesis, DNA Binding and Antitumor Evaluation of Styelsamine and Cystodytin Analogues

Synthesis, DNA Binding and Antitumor Evaluation of Styelsamine and Cystodytin Analogues

A series of N-14 sidechain substituted analogues of styelsamine (pyrido[4,3,2-mn]acridine) and cystodytin (pyrido[4,3,2-mn]acridin-4-one) alkaloids have been prepared and evaluated for their DNA binding affinity and antiproliferative activity towards a panel of human tumor cell lines. Overall it was...

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Bibliographic Details
Main Authors: Hugo K. H. Fong, Brent R. Copp
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Marine Drugs
Subjects:
marine natural products
styelsamine
cystodytin
pyridoacridine
DNA binding
Online Access:http://www.mdpi.com/1660-3397/11/2/274

Internet

http://www.mdpi.com/1660-3397/11/2/274

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