Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication

Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication

Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Curre...

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Bibliographic Details
Main Authors: Terry L. Bowlin, Donald T. Moir, Michelle M. Butler, James C. Burnett, Bing Li, Norton P. Peet
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
inum neurotoxin
inhibitor
drug discovery
Online Access:http://www.mdpi.com/1420-3049/16/1/202/

Internet

http://www.mdpi.com/1420-3049/16/1/202/

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