KRAS oncogene in lung cancer: focus on molecularly driven clinical trials

KRAS mutations are the most frequent molecular abnormalities found in one out of four nonsmall cell lung cancers (NSCLC). Their incidence increases in cases of adenocarcinoma, smokers and Caucasian patients. Their negative value in terms of prognosis and responsiveness to both standard chemotherapy...

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Bibliographic Details
Main Authors: Emmanuelle Kempf, Benoît Rousseau, Benjamin Besse, Luis Paz-Ares
Format: Article
Language:English
Published: European Respiratory Society 2016-03-01
Series:European Respiratory Review
Online Access:http://err.ersjournals.com/content/25/139/71.full