Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1

Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1

Steinert disease, or myotonic dystrophy type 1 (DM1), is a multisystemic disorder caused by toxic noncoding CUG repeat transcripts, leading to altered levels of two RNA binding factors, MBNL1 and CELF1. The contribution of CELF1 to DM1 phenotypes is controversial. Here, we show that the Drosophila C...

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Bibliographic Details
Main Authors: Lucie Picchio, Vincent Legagneux, Stephane Deschamps, Yoan Renaud, Sabine Chauveau, Luc Paillard, Krzysztof Jagla
Format: Article
Language:English
Published: The Company of Biologists 2018-05-01
Series:Disease Models & Mechanisms
Subjects:
Bruno-3
RNA CLIP
CELF1
Drosophila
mRNA stability
Myotonic dystrophy type 1
Online Access:http://dmm.biologists.org/content/11/5/dmm031849

Internet

http://dmm.biologists.org/content/11/5/dmm031849

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