Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy

Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy

Lysosomal-associated protein transmembrane 5 (LAPTM5) is mainly expressed in immune cells and has been reported to regulate inflammation, apoptosis and autophagy. Although LAPTM5 is expressed in the heart, whether LAPTM5 plays a role in regulating cardiac function remains unknown. Here, we show that...

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Bibliographic Details
Main Authors: Lu Gao, Sen Guo, Rui Long, Lili Xiao, Rui Yao, Xiaolin Zheng, Yanzhou Zhang, Xiaofang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
LAPTM5
cardiac hypertrophy
signal transduction
Rac1
MEK-ERK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.740526/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.740526/full

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