Chronic Microcystin-LR Exposure Induces Hepatocarcinogenesis via Increased Gankyrin in Vitro and in Vivo

Chronic Microcystin-LR Exposure Induces Hepatocarcinogenesis via Increased Gankyrin in Vitro and in Vivo

Background/Aims: Our recent study indicated that the serum microcystin-LR (MC-LR) level is positively linked to the risk of human hepatocellular carcinoma (HCC). Gankyrin is over-expressed in cancers and mediates oncogenesis; however, whether MC-LR induces tumor formation and the role of gankyrin in...

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Bibliographic Details
Main Authors: Lixiong He, Yujing Huang, Qiaonan Guo, Hui Zeng, Chuanfen Zheng, Jia Wang, Ji-an Chen, Lingqiao Wang, Weiqun Shu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Microcystin-LR
Gankyrin
Malignant transformation
Oncogene
Hepatocellular carcinoma
Online Access:https://www.karger.com/Article/FullText/493446

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https://www.karger.com/Article/FullText/493446

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