Eosinophils Suppress the Migration of T Cells Into the Brain of Plasmodium berghei-Infected Ifnar1-/- Mice and Protect Them From Experimental Cerebral Malaria

Eosinophils Suppress the Migration of T Cells Into the Brain of Plasmodium berghei-Infected Ifnar1-/- Mice and Protect Them From Experimental Cerebral Malaria

Cerebral malaria is a potentially lethal disease, which is caused by excessive inflammatory responses to Plasmodium parasites. Here we use a newly developed transgenic Plasmodium berghei ANKA (PbAAma1OVA) parasite that can be used to study parasite-specific T cell responses. Our present study demons...

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Bibliographic Details
Main Authors: Johanna F. Scheunemann, Julia J. Reichwald, Patricia Jebett Korir, Janina M. Kuehlwein, Lea-Marie Jenster, Christiane Hammerschmidt-Kamper, Matthew D. Lewis, Katrin Klocke, Max Borsche, Kim E. Schwendt, Camille Soun, Stephanie Thiebes, Andreas Limmer, Daniel R. Engel, Ann-Kristin Mueller, Achim Hoerauf, Marc P. Hübner, Beatrix Schumak
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
experimental cerebral malaria (ECM)
IFNAR1
malaria
CD8 T cells
eosinophils
Plasmodium berghei
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.711876/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.711876/full

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