Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine

Model‐based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine

Abstract Background Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein‐coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations...

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Bibliographic Details
Main Authors: Emma C. E. Meessen, Fianne L. P. Sips, Hannah M. Eggink, Martijn Koehorst, Johannes A. Romijn, Albert K. Groen, Natal A. W. vanRiel, Maarten R. Soeters
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Physiological Reports
Subjects:
interindividual variability
intraindividual variability
mathematical modeling
mixed meal test
postprandial bile acid metabolism
Online Access:https://doi.org/10.14814/phy2.14358

Internet

https://doi.org/10.14814/phy2.14358

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