Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis

Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis

The Notch signaling pathway is a critical player in embryogenesis but also plays various roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations, deletions, amplifications, or over-expression of Notch receptors, ligands, and a growing list of downstream Notch-activated...

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Bibliographic Details
Main Authors: Julia O. Misiorek, Alicja Przybyszewska-Podstawka, Joanna Kałafut, Beata Paziewska, Katarzyna Rolle, Adolfo Rivero-Müller, Matthias Nees
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
Notch signaling pathway
tumor progression
oncogenic mutations
tumor suppressor gene
gain and loss of function mutations (GOF and LOF)
epithelial-mesenchymal transition (EMT), angiogenesis
Online Access:https://www.mdpi.com/2073-4409/10/1/94

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https://www.mdpi.com/2073-4409/10/1/94

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