The matching quality of experimental and control interventions in blinded pharmacological randomised clinical trials: a methodological systematic review

Abstract Background Blinding is a pivotal method to avoid bias in randomised clinical trials. In blinded drug trials, experimental and control interventions are often designed to be matched, i.e. to appear indistinguishable. It is unknown how often matching procedures are inadequate, so we decided t...

Full description

Bibliographic Details
Main Authors: Segun Bello, Maoling Wei, Jørgen Hilden, Asbjørn Hróbjartsson
Format: Article
Language:English
Published: BMC 2016-02-01
Series:BMC Medical Research Methodology
Online Access:http://link.springer.com/article/10.1186/s12874-016-0111-9