Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts

Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts

<p>Abstract</p> <p>Background</p> <p>Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process. We previously revealed the importance of the mevalonate cascade in the fi...

Full description

Bibliographic Details
Main Authors: Ghavami Saeid, Mutawe Mark M, McNeill Karol D, Schaafsma Dedmer, Unruh Helmut, Jacques Eric, Laviolette Michel, Chakir Jamila, Halayko Andrew J
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Respiratory Research
Subjects:
airway fibroblasts
airway remodeling
asthma
fibronectin
geranylgeranyl transferase
statins
Online Access:http://respiratory-research.com/content/12/1/113

Internet

http://respiratory-research.com/content/12/1/113

Similar Items