ACTIVATION OF PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C IN BREAST AND OVARIAN CANCER:IMPACT ON MRS-DETECTED CHOLINE METABOLIC PROFILE AND PERSPECTIVES FOR TARGETED THERAPY

ACTIVATION OF PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C IN BREAST AND OVARIAN CANCER:IMPACT ON MRS-DETECTED CHOLINE METABOLIC PROFILE AND PERSPECTIVES FOR TARGETED THERAPY

Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine-cycle in cancer cells plays in favor of the use of metabolic imaging in oncology and opens the way for designing new targeted therapies. The anomalous choline metabolic profile detected in cancer by magnetic resonance sp...

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Bibliographic Details
Main Authors: Franca Podo, Luisa Paris, Serena Cecchetti, Francesca Spadaro, Laura Abalsamo, Carlo Ramoni, Alessandro Ricci, Maria Elena Pisanu, Francesco Sardanelli, Rossella Canese, Egidio Iorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Oncology
Subjects:
Choline Kinase
Magnetic Resonance Spectroscopy
breast cancer
targeted therapy
ovarian cancer
choline metabolism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00171/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00171/full

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