DCLK1 isoforms and aberrant Notch signaling in the regulation of human and murine colitis

Abstract Alternative promoter usage generates long and short isoforms (DCLK1-L and DCLK1-S) of doublecortin-like kinase-1 (DCLK1). Tight control of Notch signaling is important to prevent and restitute inflammation in the intestine. Our aim was to investigate whether Notch1–DCLK1 axis regulates the...

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Bibliographic Details
Main Authors: Badal C. Roy, Ishfaq Ahmed, Jason Stubbs, Jun Zhang, Thomas Attard, Seth Septer, Danny Welch, Shrikant Anant, Venkatesh Sampath, Shahid Umar
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00526-9