PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis

PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis

Patients infected by Leishmania braziliensis develop debilitating skin lesions. The role of inhibitory checkpoint receptors (ICRs) that induce T cell exhaustion during this disease is not known. Transcriptional profiling identified increased expression of ICRs including PD-1, PDL-1, PDL-2, TIM-3, an...

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Main Authors: Renan Garcia de Moura, Luciana Polaco Covre, Carlos Henrique Fantecelle, Vitor Alejandro Torres Gajardo, Carla Baroni Cunha, Lorenzzo Lyrio Stringari, Ashton Trey Belew, Camila Batista Daniel, Sandra Ventorin Von Zeidler, Carlos Eduardo Tadokoro, Herbert Leonel de Matos Guedes, Raphael Lubiana Zanotti, David Mosser, Aloisio Falqueto, Arne N. Akbar, Daniel Claudio Oliveira Gomes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
cutaneous leishmaniasis
Leishmania braziliensis
T cell exhaustion
PD-1
inhibitory checkpoint receptors
senescent T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.632667/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.632667/full

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