The amyloid-inhibiting NCAM-PrP peptide targets Aβ peptide aggregation in membrane-mimetic environments

The amyloid-inhibiting NCAM-PrP peptide targets Aβ peptide aggregation in membrane-mimetic environments

Summary: Substantial research efforts have gone into elucidating the role of protein misfolding and self-assembly in the onset and progression of Alzheimer’s disease (AD). Aggregation of the Amyloid-β (Aβ) peptide into insoluble fibrils is closely associated with AD. Here, we use biophysical techniq...

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Bibliographic Details
Main Authors: Sylwia Król, Nicklas Österlund, Faraz Vosough, Jüri Jarvet, Sebastian Wärmländer, Andreas Barth, Leopold L. Ilag, Mazin Magzoub, Astrid Gräslund, Cecilia Mörman
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
molecular neuroscience
structural biology
biophysics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008208

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http://www.sciencedirect.com/science/article/pii/S2589004221008208

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