Rosiglitazone and AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells.

Rosiglitazone and AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells.

PPARs are nuclear receptors activated by ligands. Activation of PPARγ leads to a reduction of adhesion and motility in some cancer models. PPARγ transcriptional activity can be negatively regulated by JNK-mediated phosphorylation. We postulated that the use of agents able to inhibit JNK activity cou...

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Bibliographic Details
Main Authors: Angelo Cerbone, Cristina Toaldo, Rosalba Minelli, Eric Ciamporcero, Stefania Pizzimenti, Piergiorgio Pettazzoni, Guglielmo Roma, Mario Umberto Dianzani, Chiara Ullio, Carlo Ferretti, Chiara Dianzani, Giuseppina Barrera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3386191?pdf=render

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http://europepmc.org/articles/PMC3386191?pdf=render

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