Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer

Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer

Abstract Background Adjuvant gemcitabine for pancreatic cancer has limited efficacy in the clinical setting. Impaired drug metabolism is associated with treatment resistance. We aimed to evaluate the chemosensitising effect of interferon-beta (IFN-β). Methods BxPC-3, CFPAC-1, and Panc-1 cells were p...

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Bibliographic Details
Main Authors: Amber Blaauboer, Stephanie Booy, Peter M. van Koetsveld, Bas Karels, Fadime Dogan, Suzanne van Zwienen, Casper H. J. van Eijck, Leo J. Hofland
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
Interferon-beta
Gemcitabine
Chemosensitising effect
Drug transporters
Online Access:http://link.springer.com/article/10.1186/s12885-020-07420-0

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http://link.springer.com/article/10.1186/s12885-020-07420-0

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