Regulated phosphorylation of the K-Cl cotransporter KCC3 at dual C-terminal threonines is a potent switch of intracellular potassium content and cell volume homeostasis

Regulated phosphorylation of the K-Cl cotransporter KCC3 at dual C-terminal threonines is a potent switch of intracellular potassium content and cell volume homeostasis

The defense of cell volume against excessive shrinkage or swelling is a requirement for cell function and organismal survival. Cell swelling triggers a coordinated homeostatic response termed regulatory volume decrease (RVD), resulting in K+ and Cl– efflux via the activation of K+ channels, volume-r...

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Bibliographic Details
Main Authors: Norma C. Adragna, Nagendra Babu Ravilla, Peter K. Lauf, Gulnaz eBegum, Arjun R. Khanna, Dandan eSun, Kristopher T Kahle
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Chloride Channels
GABA Modulators
KCC2
neuropathic pain
Autism Spectrum Disorders
NKCC1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00255/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00255/full

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