Histone chaperone HIRA dictate proliferation vs differentiation of chronic myeloid leukemia cells

Histone chaperone HIRA dictate proliferation vs differentiation of chronic myeloid leukemia cells

Abstract Abnormal proliferation and disrupted differentiation of hematopoietic progenitors mark leukemia. Histone cell cycle regulator A (HIRA), a histone chaperone, regulates hemogenic to hematopoietic transition involved in normal hematopoiesis. But, its role remains unexplored in leukemia, a case...

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Bibliographic Details
Main Authors: Aditi Majumder, Arya T. Dharan, Ishita Baral, Pallavi Chinnu Varghese, Ananda Mukherjee, Lakshmi Subhadradevi, Geetha Narayanan, Debasree Dutta
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:FASEB BioAdvances
Subjects:
GATA2
hematopoietic precursors
histone variant H3.3
MKL1
proliferation
Online Access:https://doi.org/10.1096/fba.2019-00014

Internet

https://doi.org/10.1096/fba.2019-00014

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