Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

Abstract Background Alzheimer’s disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical ginger sesquiterpene, in transgenic APP/PS1 mice, rodent models of AD...

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Bibliographic Details
Main Authors: Lei Li, Xiang-Hui Wu, Xiao-Jing Zhao, Lu Xu, Cai-Long Pan, Zhi-Yuan Zhang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
APP/PS1 transgenic mouse
Zerumbone
Cerebral amyloidosis
Neuroinflammation
MAPK signaling pathway
Online Access:http://link.springer.com/article/10.1186/s12974-020-01744-1

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http://link.springer.com/article/10.1186/s12974-020-01744-1

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