Osteogenic Response to Polysaccharide Nanogel Sheets of Human Fibroblasts After Conversion Into Functional Osteoblasts by Direct Phenotypic Cell Reprogramming

Osteogenic Response to Polysaccharide Nanogel Sheets of Human Fibroblasts After Conversion Into Functional Osteoblasts by Direct Phenotypic Cell Reprogramming

Human dermal fibroblasts (HDFs) were converted into osteoblasts using a ALK inhibitor II (inhibitor of transforming growth factor-β signal) on freeze-dried nanogel-cross-linked porous (FD-NanoClip) polysaccharide sheets or fibers. Then, the ability of these directly converted osteoblasts (dOBs) to p...

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Bibliographic Details
Main Authors: Kei Nakai, Kenta Yamamoto, Tsunao Kishida, Shin-ichiro Kotani, Yoshiki Sato, Satoshi Horiguchi, Hironaka Yamanobe, Tetsuya Adachi, Francesco Boschetto, Elia Marin, Wenliang Zhu, Kazunari Akiyoshi, Toshiro Yamamoto, Narisato Kanamura, Giuseppe Pezzotti, Osam Mazda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
nanogel
polysaccharide
fibroblast
cell reprogramming
osteogenic
osteoblast
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.713932/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.713932/full

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