Design, Synthesis, and Biological Evaluation of Novel 6<i>H</i>-Benzo[<i>c</i>]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors

Design, Synthesis, and Biological Evaluation of Novel 6<i>H</i>-Benzo[<i>c</i>]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors

Urolithins (hydroxylated 6<i>H</i>-benzo[<i>c</i>]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series of alkoxylated 6<i>...

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Bibliographic Details
Main Authors: Long Tang, Jianchun Jiang, Guoqiang Song, Yajing Wang, Ziheng Zhuang, Ying Tan, Yan Xia, Xianfeng Huang, Xiaoqing Feng
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
alkoxylated 6<i>H</i>-benzo[<i>c</i>]chromen-6-one
phosphodiesterase II
inhibitors
biological activities
Online Access:https://www.mdpi.com/1422-0067/22/11/5680

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https://www.mdpi.com/1422-0067/22/11/5680

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