Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine

Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testing of colorectal carcinoma-derived PDX. We generat...

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Bibliographic Details
Main Authors: Maria Rivera, Iduna Fichtner, Annika Wulf-Goldenberg, Christine Sers, Johannes Merk, Giannino Patone, Keziban M. Alp, Tamara Kanashova, Philipp Mertins, Jens Hoffmann, Ulrike Stein, Wolfgang Walther
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colorectal carcinoma
Patient-derived xenograft models
In vivo drug testing
Personalized medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301731

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http://www.sciencedirect.com/science/article/pii/S1476558620301731

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