A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases

A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases

Voltage sensitive phosphatases (VSPs), including engineered voltage sensitive PTEN, are excellent tools to rapidly and reversibly alter the phosphoinositide (PI) content of the plasma membrane in vivo and study the tumor suppressor PTEN. However, widespread adoption of these tools is hampered by the...

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Bibliographic Details
Main Authors: Angeliki eMavrantoni, Veronika eThallmair, Michael G Leitner, Daniela N Schreiber, Dominik eOliver, Christian R Halaszovich
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
Fluorescence Resonance Energy Transfer
Signal Transduction
Cancer
phosphoinositides
Voltage sensitive phosphatase (VSP)
Phosphatase and tensin homologue (PTEN)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00068/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00068/full

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