RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.

RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.

The sensing of pathogen infection and subsequent triggering of innate immunity are key to controlling zoonotic infections. Myxoma virus (MV) is a cytoplasmic DNA poxvirus that in nature infects only rabbits. Our previous studies have shown that MV infection of primary mouse cells is restricted by vi...

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Bibliographic Details
Main Authors: Fuan Wang, Xiujuan Gao, John W Barrett, Qing Shao, Eric Bartee, Mohamed R Mohamed, Masmudur Rahman, Steve Werden, Timothy Irvine, Jingxin Cao, Gregory A Dekaban, Grant McFadden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2438611?pdf=render

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http://europepmc.org/articles/PMC2438611?pdf=render

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