Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease

Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease

The mechanism underlying selective motor neuron (MN) death remains an essential question in the MN disease field. The MN disease spinal muscular atrophy (SMA) is attributable to reduced levels of the ubiquitous protein SMN. Here, we report that SMN levels are widely variable in MNs within a single g...

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Bibliographic Details
Main Authors: Natalia Rodriguez-Muela, Nadia K. Litterman, Erika M. Norabuena, Jesse L. Mull, Maria José Galazo, Chicheng Sun, Shi-Yan Ng, Nina R. Makhortova, Andrew White, Maureen M. Lynes, Wendy K. Chung, Lance S. Davidow, Jeffrey D. Macklis, Lee L. Rubin
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
spinal muscular atrophy
amyotrophic lateral sclerosis
survival of motor neuron
single cell analysis
cell heterogeneity
therapeutics
protein degradation
cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300724

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http://www.sciencedirect.com/science/article/pii/S2211124717300724

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