Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model

Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model

GD2-redirected chimeric antigen receptor (CAR) T lymphocytes represent a promising therapeutic option for immunotherapy of neuroblastoma (NB). However, despite the encouraging therapeutic effects observed in some hematological malignancies, clinical results of CAR T cell immunotherapy in solid tumor...

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Bibliographic Details
Main Authors: Paola Bocca, Emma Di Carlo, Ignazio Caruana, Laura Emionite, Michele Cilli, Biagio De Angelis, Concetta Quintarelli, Annalisa Pezzolo, Lizzia Raffaghello, Fabio Morandi, Franco Locatelli, Vito Pistoia, Ignazia Prigione
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
angiogenesis
bevacizumab
car t cells
immunotherapy
neuroblastoma
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1378843

Internet

http://dx.doi.org/10.1080/2162402X.2017.1378843

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