Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model
GD2-redirected chimeric antigen receptor (CAR) T lymphocytes represent a promising therapeutic option for immunotherapy of neuroblastoma (NB). However, despite the encouraging therapeutic effects observed in some hematological malignancies, clinical results of CAR T cell immunotherapy in solid tumor...
Main Authors: | Paola Bocca, Emma Di Carlo, Ignazio Caruana, Laura Emionite, Michele Cilli, Biagio De Angelis, Concetta Quintarelli, Annalisa Pezzolo, Lizzia Raffaghello, Fabio Morandi, Franco Locatelli, Vito Pistoia, Ignazia Prigione |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2018-01-01
|
Series: | OncoImmunology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/2162402X.2017.1378843 |
Similar Items
-
MYCN: From Oncoprotein To Tumor-Associated Antigen
by: Vito ePistoia, et al.
Published: (2012-11-01) -
A novel mechanism of soluble HLA-G mediated immune modulation: downregulation of T cell chemokine receptor expression and impairment of chemotaxis.
by: Fabio Morandi, et al.
Published: (2010-07-01) -
Immunosuppressive microenvironment in neuroblastoma
by: Vito ePistoia, et al.
Published: (2013-06-01) -
Tumor mRNA-Transfected Dendritic Cells Stimulate the Generation of CTL That Recognize Neuroblastoma-Associated Antigens, Kill Tumor Cells: Immunotherapeutic Implications
by: Fabio Morandi, et al.
Published: (2006-10-01) -
Close interactions between mesenchymal stem cells and neuroblastoma cell lines lead to tumor growth inhibition.
by: Giovanna Bianchi, et al.
Published: (2012-01-01)