Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1+ stem cells from young donors

Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1+ stem cells from young donors

Abstract Background Radiotherapy is widely used and effective for treating brain tumours, but inevitably impairs cognition as it arrests cellular processes important for learning and memory. This is particularly evident in the aged brain with limited regenerative capacity, where radiation produces i...

Full description

Bibliographic Details
Main Authors: Lukasz Wlodarek, Feng Cao, Faisal J. Alibhai, Adam Fekete, Nima Noyan, Stephanie W. Tobin, Tina B. Marvasti, Jun Wu, Shu-Hong Li, Richard D. Weisel, Lu-Yang Wang, Zhengping Jia, Ren-Ke Li
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Radiotherapy
Aging
Microglia
Learning and memory
Bone marrow stem cells
Online Access:https://doi.org/10.1186/s12974-019-1681-3

Internet

https://doi.org/10.1186/s12974-019-1681-3

Similar Items