The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.

The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.

Hepatitis C virus (HCV) assembly is still poorly understood. It is thought that trafficking of the HCV core protein to the lipid droplet (LD) surface is essential for its multimerization and association with newly synthesized HCV RNA to form the viral nucleocapsid. We carried out a mapping analysis...

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Bibliographic Details
Main Authors: Loïc Etienne, Emmanuelle Blanchard, Audrey Boyer, Virginie Desvignes, Julien Gaillard, Jean-Christophe Meunier, Philippe Roingeard, Christophe Hourioux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4560444?pdf=render

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http://europepmc.org/articles/PMC4560444?pdf=render

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