Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film

Physiologically Based Pharmacokinetic Modeling to Understand the Absorption of Risperidone Orodispersible Film

ObjectiveThe aim of the present study was to investigate the absorption routes as well as the potential application of the oral transmucosal delivery of risperidone orodispersible film (ODF) using physiologically based pharmacokinetic modeling.MethodsThe pharmacokinetic study after intragastric (i.g...

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Bibliographic Details
Main Authors: Fang Chen, Hongrui Liu, Bing Wang, Liuliu Yang, Weimin Cai, Zheng Jiao, Zhou Yang, Yusheng Chen, Yingjun Quan, Xiaoqiang Xiang, Hao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
risperidone orodispersible film
oral cavity compartment absorption and transit model
advanced compartment absorption and transit model
GastroPlus™
oral residence time
oral transmucosal delivery
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01692/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01692/full

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