15-Lipoxygenase-1 Expression Upregulates and Activates Insulin-Like Growth Factor-1 Receptor in Prostate Cancer Cells
We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PC...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-01-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558604800526 |