Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

Abstract Background Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia. The neuroinflammatory response to traumatic brain injury (TBI) represents a key...

Full description

Bibliographic Details
Main Authors: Seiya Takada, Harutoshi Sakakima, Takahiro Matsuyama, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Yuki Itashiki, Akira Tani, Kiyoshi Kikuchi
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Midkine
Traumatic brain injury
Microglia/macrophages
M1/M2 phenotype
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-020-1709-8

Internet

https://doi.org/10.1186/s12974-020-1709-8

Similar Items