DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice.

DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice.

Studies disrupting the chemokine pathway CX3CL1 (fractalkine)/ CX3CR1 have shown decreased atherosclerosis in animal models but the techniques used to interrupt the pathway have not been easily translatable into human trials. DNA vaccination potentially overcomes the translational difficulties. We e...

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Bibliographic Details
Main Authors: Jimmy Jianheng Zhou, Yuan Min Wang, Vincent W S Lee, Geoff Yu Zhang, Heather Medbury, Helen Williams, Ya Wang, Thian Kui Tan, David C H Harris, Stephen I Alexander, Anne M Durkan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5895033?pdf=render

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http://europepmc.org/articles/PMC5895033?pdf=render

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