Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

Francisella tularensis infects macrophages and escapes phago-lysosomal fusion to replicate within the host cytosol, resulting in host cell apoptosis. Here we show that the Fas-mediated death pathway is activated in infected cells and correlates with escape of the bacterium from the phagosome and the...

Full description

Bibliographic Details
Main Authors: Murugesan V S Rajaram, Jonathan P Butchar, Kishore V L Parsa, Thomas J Cremer, Amal Amer, Larry S Schlesinger, Susheela Tridandapani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2775408?pdf=render

Internet

http://europepmc.org/articles/PMC2775408?pdf=render

Similar Items